Piezo 1 is involved in intraocular pressure regulation
نویسندگان
چکیده
منابع مشابه
Bestrophin-2 is involved in the generation of intraocular pressure.
PURPOSE The bestrophin family of proteins has been demonstrated to generate or regulate Ca2+-activated Cl(-) conductances. Mutations in bestrophin-1 (Best1) cause several blinding eye diseases, but little is known about other bestrophin family members. This study involved disruption of the Best2 gene in mice. METHODS The mouse Best2 gene was disrupted by replacing exons 1, 2, and part of exon...
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Fluid shear modulates many biological properties. How shear mechanosensing occurs in the extracellular matrix (ECM) and is transduced into cytoskeletal change remains unknown. Cochlin is an ECM protein of unknown function. Our investigation using a comprehensive spectrum of cutting-edge techniques has resulted in following major findings: (1) over-expression and down-regulation of cochlin incre...
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The IOP reduction and regulation system performs certain specific functions: it can be used to lower (or raise) IOP in a controlled way; it responds rapidly to maintain a selectable, set, minimum IOP under variable flow demands; and it reduces the rapid dynamic increases in IOP resulting from loads applied to the eye. The system has been tested and evaluated in the laboratory with a small test ...
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Background: In many clinical situations, knowledge of central venous pressure (CVP) is important. Measurement of CVP is not always possible. Objective: To determine if intraocular pressure (IOP) can be used as an estimate for CVP. Methods: IOP and CVP were measured concurrently in 30 candidates of coronary artery bypass graft surgery. Those with carotid artery or jugular venous diseases as we...
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The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2021
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2021.06.005